Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
RNA Polymerase III
RNA Polymerase III antibodies are autoantibodies strongly associated with systemic sclerosis (scleroderma). Women are significantly more likely to develop systemic sclerosis, and hormonal factors may influence disease progression, making this test particularly relevant for women's immune health.
What It Measures
This test detects the presence and level of anti-RNA Polymerase III antibodies in your blood. These antibodies are a specific marker for a subtype of systemic sclerosis and can help guide clinical assessment.
Why It Matters
The presence of RNA Polymerase III antibodies may indicate systemic sclerosis with diffuse skin involvement and can be associated with an increased risk of renal crisis. Early detection can support timely monitoring and management of potential complications.
When to Test
Testing may be recommended when symptoms of systemic sclerosis are present, such as skin thickening, Raynaud's phenomenon, or difficulty swallowing. It is also used as part of a comprehensive autoimmune antibody panel. Consult a healthcare professional for interpretation of results.
Symptoms
Low Levels
Absence of RNA Polymerase III antibodies is not typically associated with specific symptoms and is generally considered a standard finding
High Levels
Rapid skin thickening, Raynaud's phenomenon (colour changes in fingers and toes), difficulty swallowing, shortness of breath, joint stiffness, kidney-related symptoms such as elevated blood pressure
Lifestyle Tips
Keeping hands and feet warm can help manage Raynaud's symptoms. Gentle stretching and physical therapy may support skin and joint flexibility. Avoiding smoking is strongly recommended, as it can worsen circulation problems. Regular medical follow-up is important for monitoring disease progression.
Frequently Asked Questions
What is systemic sclerosis?
Systemic sclerosis (scleroderma) is a chronic autoimmune condition that causes thickening and hardening of the skin and can affect internal organs. RNA Polymerase III antibodies are associated with a specific subtype of this condition.
Does a positive result confirm systemic sclerosis?
A positive result is strongly associated with systemic sclerosis but must be interpreted alongside clinical symptoms, physical examination, and other diagnostic tests by a healthcare professional.
How common are RNA Polymerase III antibodies?
These antibodies are found in approximately 10 to 25 percent of patients with systemic sclerosis. They are relatively specific to this condition, making them a useful diagnostic marker.