Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
ANCA Screening
ANCA screening helps identify vasculitis conditions that can affect women of all ages. Early detection enables prompt treatment and organ preservation.
What It Measures
This screening test detects ANCA antibodies and classifies them as c-ANCA (cytoplasmic, typically anti-PR3) or p-ANCA (perinuclear, typically anti-MPO). The pattern helps differentiate between vasculitis types.
Why It Matters
ANCA-associated vasculitis can affect kidneys, lungs, and other organs with potentially life-threatening consequences. Early detection enables prompt immunosuppressive treatment.
When to Test
Testing can be indicated for suspected vasculitis: unexplained kidney disease with active sediment, pulmonary-renal syndrome, recurrent sinusitis with systemic symptoms, or unexplained multi-organ inflammation.
Symptoms
Low Levels
A negative ANCA result makes ANCA-associated vasculitis less likely but does not completely exclude it, particularly in limited disease forms.
High Levels
A positive ANCA may be associated with vasculitis symptoms including fatigue, weight loss, fever, joint pain, skin lesions, kidney dysfunction, respiratory symptoms, and nerve damage.
Lifestyle Tips
If ANCA is positive with symptoms, urgent referral to a specialist is important as vasculitis can progress rapidly. Treatment typically involves immunosuppressive therapy. Regular monitoring of kidney function and blood counts is essential during treatment.
Frequently Asked Questions
What is ANCA-associated vasculitis?
A group of autoimmune conditions causing inflammation of small blood vessels. GPA, MPA, and EGPA are the main types, each with distinct features.
What is the difference between c-ANCA and p-ANCA?
c-ANCA (anti-PR3) is most commonly associated with GPA. p-ANCA (anti-MPO) is more common in MPA. The pattern helps guide diagnosis.
Can vasculitis be treated?
Yes. Modern immunosuppressive therapy has dramatically improved outcomes. Most patients achieve remission, though long-term monitoring for relapse is important.