Doctor's Assessment Included
Every result includes a professional assessment from a BIG-registered doctor. For treatment decisions, discuss your results with your GP.
Anti ds-DNA + ss-DNA
Anti ds-DNA is crucial for women, as SLE affects women approximately 9 times more often than men, particularly during reproductive years. It helps diagnose and monitor disease activity.
What It Measures
This test measures antibodies directed against both double-stranded and single-stranded DNA. Anti-dsDNA is the more clinically significant component and is included in SLE classification criteria.
Why It Matters
Anti-dsDNA is one of the most specific markers for SLE and is included in the ACR/EULAR classification criteria. Rising titres may predict lupus flares, especially renal involvement.
When to Test
Testing could be indicated when SLE is suspected, for monitoring known SLE disease activity, or when ANA is positive and further characterisation is needed.
Symptoms
Low Levels
A negative result makes SLE less likely but does not exclude it. Some SLE patients are anti-dsDNA negative, particularly those with mild or cutaneous-predominant disease.
High Levels
Elevated anti-dsDNA in the context of compatible symptoms strongly supports SLE diagnosis. High titres are particularly associated with lupus nephritis and may fluctuate with disease activity.
Lifestyle Tips
If anti-dsDNA positive, consult a rheumatologist. Sun protection is essential as UV exposure can trigger lupus flares. Maintain regular monitoring of kidney function and disease activity markers.
Frequently Asked Questions
How specific is anti-dsDNA for lupus?
Anti-dsDNA has approximately 95% specificity for SLE, making it one of the most useful confirmatory tests when lupus is suspected.
Do anti-dsDNA levels correlate with disease activity?
Often yes, particularly for renal involvement. Rising titres may precede clinical flares, making it useful for monitoring.
What is the difference between dsDNA and ssDNA antibodies?
Anti-dsDNA is highly specific for SLE. Anti-ssDNA is less specific and can be found in drug-induced lupus and other autoimmune conditions.