Allergy & Intolerance

Tryptase Test

Tryptase measures mast cell activity. For women with severe allergy history, a baseline is important especially when planning pregnancy.

Doctor's Assessment Included

Tryptase: what this test measures

This test measures total tryptase concentration. Acute tryptase peaks 1-2 hours after anaphylaxis. Baseline tryptase reflects overall mast cell burden.

Tryptase: why this value matters

Elevated baseline tryptase may indicate mastocytosis. Acute elevation supports anaphylaxis diagnosis. Knowing your baseline enables comparison during future allergic emergencies.

Tryptase: when is testing worthwhile?

Baseline tryptase is recommended for individuals with severe allergic reaction history, suspected mastocytosis, or unexplained anaphylaxis. During events, draw blood 1-2 hours after symptom onset.

Tryptase: symptoms of a high or low value

Low Levels

Low tryptase levels are normal and suggest low mast cell burden. Mast cell disorders are unlikely.

High Levels

Elevated baseline tryptase may indicate mastocytosis or hereditary alpha-tryptasaemia. Acutely elevated tryptase suggests anaphylaxis. Symptoms may include severe flushing, low blood pressure, and breathing difficulty.

Tryptase: lifestyle and this value

If elevated baseline tryptase is found, work with an allergist to determine the cause. Carry emergency medication if prescribed and wear medical identification. Avoid known triggers.

Tryptase: frequently asked questions

Why should I know my baseline tryptase?

It allows comparison during suspected allergic emergencies. A significant rise above baseline strongly supports anaphylaxis diagnosis.

What is mastocytosis?

A condition where abnormal mast cells accumulate in tissues. It can cause flushing, itching, and severe reactions. Elevated baseline tryptase is a diagnostic criterion.

When should tryptase be drawn after a reaction?

Ideally 1-2 hours after symptom onset. A second sample at 24 hours provides your baseline for comparison.

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