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Allergy & Intolerance

Total IgA: Normal Values and Why It Is Measured in Coeliac Testing

Total IgA measures mucosal immune defence and validates coeliac tests. Women are more likely to have autoimmune conditions associated with IgA abnormalities.

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Total IgA: what this test measures

This test measures the total concentration of immunoglobulin A in your blood serum, providing an overall assessment of IgA production.

Total IgA: why this value matters

IgA deficiency affects about 1 in 500 people and is essential to measure alongside coeliac antibody tests because deficiency renders these tests unreliable. Low IgA may also be associated with increased susceptibility to mucosal infections.

Total IgA: when is testing worthwhile?

Total IgA should be measured alongside coeliac disease antibody tests to validate reliability. It could also be indicated when recurrent mucosal infections are present.

Total IgA: symptoms of a high or low value

Low Levels

Selective IgA deficiency may be asymptomatic or associated with recurrent sinusitis, respiratory infections, and gastrointestinal infections. It also causes false-negative IgA-based antibody tests.

High Levels

Elevated total IgA may be seen in chronic infections, inflammatory bowel disease, liver disease, IgA nephropathy, and autoimmune conditions.

Total IgA: lifestyle and this value

If IgA deficiency is confirmed, inform your healthcare providers so they use IgG-based tests for coeliac screening. Practice good hygiene, stay vaccinated, and report recurrent infections promptly.

Total IgA: frequently asked questions

Why is total IgA tested with coeliac antibodies?

Most coeliac blood tests are IgA-based. IgA deficiency makes these tests falsely negative. Measuring total IgA ensures test reliability.

Is IgA deficiency serious?

Most people with selective IgA deficiency are healthy. The main importance is knowing about it to avoid false-negative tests.

Can IgA deficiency be treated?

There is no specific treatment. Management focuses on treating infections and using alternative tests when needed.

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Tests with related values

These panels measure values from the same category as this marker.

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Total IgA

€114,-