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Cardiovascular

Omega-3 Index Test

The Omega-3 Index reflects your long-term omega-3 status, which may support cardiovascular protection, mood balance, and healthy pregnancy outcomes.

Doctor's Assessment Included

When is this value abnormal?

Decision limits per result, in % fs ges.
Result Value (% fs ges.)
Deficiency < 4
Insufficient 4–8
Target met ≥ 8

The Omega-3 Index measures EPA and DHA as a percentage of the total fatty acids in red blood cell membranes. The laboratory applies the same limits on your result: < 4.0 low cardioprotection, 4.0–8.0 moderate, > 8.0 good. The target value in the literature is 8–11 %; the Dutch average is 6.06 % (n = 1,974), so below the target. The limits apply only to the standardised measurement in red blood cells; a measurement in serum or plasma cannot be compared with these values.

Source: Netherlands Heart Journal Reference population: Dutch population (Neth Heart J 2023, n = 1,974; mean 6.06 %)

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

Omega-3 Index: what this test measures

This test measures EPA and DHA as a percentage of total fatty acids in red blood cell membranes, reflecting omega-3 intake over the previous 2-3 months.

Omega-3 Index: why this value matters

An Omega-3 Index above 8% is generally associated with lower cardiovascular risk. Values below 4% may indicate increased risk. It is a modifiable marker that responds well to dietary changes. Consult your healthcare provider.

Omega-3 Index: how the blood test works

Referral
No GP referral needed. After the order we arrange the referral through ZorgDomein, within one business day; orders after 17:00 or at the weekend start on the next business day. ZorgDomein emails a barcode, and that barcode is what the draw site needs.
The draw
A blood draw from a vein in the arm, at a partner laboratory's draw site. No home kit, no finger prick.
Where
650+ draw sites run by independent laboratories across the Netherlands. Draw sites

Omega-3 Index: when is testing worthwhile?

Testing may be recommended as part of cardiovascular risk assessment, to evaluate omega-3 supplementation effectiveness, or to guide nutritional optimisation.

Omega-3 Index: symptoms of a high or low value

Low Levels

A low Omega-3 Index does not cause direct symptoms but may be associated with increased cardiovascular risk and a more pro-inflammatory state.

High Levels

A high Omega-3 Index is generally favourable and associated with cardiovascular protection. Very high levels are rare and not typically a concern.

Omega-3 Index: what to do about an abnormal value

Female

If Low

Low omega-3 index increases cardiovascular risk. Consider fish oil supplementation or more oily fish.

If High

High omega-3 index is protective for heart health.

Omega-3 Index: lifestyle and this value

Eat fatty fish at least twice per week (salmon, mackerel, sardines). Consider a quality omega-3 supplement if dietary intake is insufficient. Results typically improve within 2-3 months of consistent intake changes.

Omega-3 Index: frequently asked questions

What is a good Omega-3 Index?

An Omega-3 Index of 8% or higher is generally considered optimal for cardiovascular protection. Below 4% is considered high risk. Your healthcare provider can interpret your specific result.

How quickly can I improve my Omega-3 Index?

With consistent dietary changes or supplementation, improvements may be seen within 2-3 months, as the test reflects red blood cell turnover.

Is the Omega-3 Index better than measuring blood omega-3?

The Omega-3 Index reflects long-term omega-3 status (similar to HbA1c for glucose), making it more stable and clinically useful than a single blood measurement.

Omega-3 Index: sources

  1. von Schacky C, Kuipers RS, Pijl H, Muskiet FAJ, Grobbee DE. Omega-3 fatty acids in heart disease — why accurately measured levels matter. Neth Heart J 2023;31(11):415–423. PMID 36795219. DOI 10.1007/s12471-023-01759-2. Grenswaarden oorspronkelijk uit: Harris WS, von Schacky C. The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med 2004;39(1):212–20. PMID 15208005. (retrieved 2026) pmc.ncbi.nlm.nih.gov

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Tests with related values

These panels measure values from the same category as this marker.

Medical reviewer

Medical standards

Dr. Naimi oversees the medical standards behind our content and assessments.

Medical policy
CIBG Ministerie van Volksgezondheid,
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Omega-3 Index

€163,-