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Hormones

Estradiol (E2)

Estradiol (E2) is the primary estrogen guiding your menstrual cycle, fertility, and menopausal transition. Fluctuating levels may indicate changes in ovarian function. Your healthcare provider can help you understand what your results mean for your cycle and overall health.

Doctor's Assessment Included

Reference Ranges

Female
pmol/l
Low 46 Normal 607 High

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

Check your own value

What It Measures

This test measures the concentration of estradiol (E2) in your blood. Estradiol is produced primarily by the ovaries in women and in smaller amounts by the testes and adrenal glands in men. Your healthcare provider may use this result alongside other hormone levels.

Why It Matters

Estradiol orchestrates ovulation, supports uterine lining, and influences mood throughout your cycle. During perimenopause, declining levels could suggest approaching menopause. Tracking estradiol with your healthcare provider may offer valuable insight into your reproductive and hormonal health.

When to Test

Your healthcare provider may recommend testing estradiol when investigating irregular menstrual cycles, fertility concerns, menopausal symptoms, or unexplained mood changes. For men, testing could be suggested when evaluating gynecomastia or other hormonal concerns. Consult your provider for personalised timing advice.

Symptoms

Low Levels

Some people may experience hot flashes, night sweats, mood changes, vaginal dryness, or decreased bone density when estradiol levels are low. Fatigue and difficulty concentrating could also suggest reduced estradiol. A healthcare provider can help determine the cause and recommend appropriate support.

High Levels

Elevated estradiol levels may be associated with bloating, breast tenderness, mood swings, or irregular periods in women. In men, high levels could suggest gynaecomastia or reduced libido. Your healthcare provider can evaluate whether further investigation is needed based on your symptoms.

Recommendations

Female

If Low

Low estradiol may indicate menopause, ovarian dysfunction, or eating disorders. Consider hormone replacement therapy if menopausal, or evaluation for underlying conditions.

If High

High estradiol levels may indicate ovarian tumors, pregnancy, or hormone therapy. Consult with a gynecologist or endocrinologist for proper evaluation.

Lifestyle Tips

Maintaining a healthy weight, regular physical activity, and a balanced diet rich in fibre and cruciferous vegetables may support healthy estrogen metabolism. Limiting alcohol intake and managing stress could also contribute to hormonal balance. Always discuss lifestyle changes with your healthcare provider.

Frequently Asked Questions

What is estradiol?
Estradiol is the strongest form of estrogen, important for reproductive and bone health.
When should I test estradiol?
Your provider may suggest testing during fertility evaluation or when experiencing hormonal symptoms.
Can lifestyle affect estradiol levels?
Diet, exercise, and body weight may influence estradiol. Discuss changes with your healthcare provider.

Test Products

This marker is included in the following test panels.

Fertility & Pregnancy

IVF Blood Test Complete (Women)

Everything in the IVF panel plus full thyroid, preconception nutrients, progesterone and CMV immunity.

TSH (Thyroid Stimulating Hormone) Prolactin AMH (Anti-Müllerian Hormone) Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) Free T4 (Thyroxine) Folate (Folic Acid) Vitamin B12 Ferritin Progesterone Vitamin D (25-OH) Chlamydia IgG HIV 1/2 Antibody + p24 Antigen Syphilis Screening Blood Type + Rh TPO Antibodies CMV IgG Hepatitis B Core Antibody Hepatitis B Surface Antigen Hepatitis C Antibody Rubella IgG Toxoplasmosis IgG Varicella Zoster D-Dimer Complete Blood Count (CBC)
€495,-
Fertility & Pregnancy

IVF Blood Test (Women)

Complete female IVF intake panel: ovarian reserve, thyroid, infectious screening, immunity serology, blood group and CBC.

TSH (Thyroid Stimulating Hormone) Prolactin AMH (Anti-Müllerian Hormone) Estradiol (E2) FSH (Follicle Stimulating Hormone) LH (Luteinizing Hormone) Chlamydia IgG HIV 1/2 Antibody + p24 Antigen Syphilis Screening Blood Type + Rh Hepatitis B Core Antibody Hepatitis B Surface Antigen Hepatitis C Antibody Rubella IgG Toxoplasmosis IgG Varicella Zoster D-Dimer Complete Blood Count (CBC)
€425,-

Estradiol (E2)

€34,-