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Hormones

Estrone (E1) Blood Test

Estrone (E1) becomes your primary estrogen during and after menopause, produced mainly in fat tissue. Monitoring E1 levels may provide insight into your menopausal transition. Your healthcare provider can help interpret what changes in estrone mean for your health journey.

Doctor's Assessment Included

Reference Ranges

No established reference range

No reliable reference interval can be established for estrone: the Dutch laboratories that offer the test publish male values that differ by a factor of 1.7, and the published values apply only to LC-MS/MS. Estrone is rarely ordered as a stand-alone test; we would rather show no value than one that is wrong.

Unit: pmol/l

Reference ranges may vary between laboratories. When you order a test, a BIG-registered doctor assesses your personal results in context. For treatment decisions, discuss your results with your GP.

Estrone (E1): what this test measures

This test measures the level of estrone (E1) in your blood. Estrone is produced by fat tissue, the adrenal glands, and the ovaries. After menopause it becomes the primary circulating estrogen. Your healthcare provider may use this result to assess your overall hormonal status.

Estrone (E1): why this value matters

As ovarian estradiol production declines, estrone becomes your body's main estrogen source. Tracking E1 levels could help your healthcare provider assess your menopausal stage, bone health risk, and whether hormonal support might be beneficial for your symptoms.

Estrone (E1): when is testing worthwhile?

Your healthcare provider may recommend estrone testing during menopause evaluation, when investigating unexplained weight changes, or as part of a comprehensive hormone panel. Testing could also be suggested for monitoring hormone replacement therapy effectiveness. Consult your provider for personalised guidance.

Estrone (E1): symptoms of a high or low value

Low Levels

Some people may experience accelerated bone loss, increased fatigue, or changes in body composition when estrone levels are low. Joint discomfort and skin changes could also suggest reduced estrogen activity. A healthcare provider can help evaluate whether your levels require attention.

High Levels

Elevated estrone levels may be associated with weight gain, bloating, breast tenderness, or irregular bleeding. High levels could suggest increased conversion from fat tissue or other hormonal imbalances. Your healthcare provider can help determine whether further investigation is appropriate.

Estrone (E1): what to do about an abnormal value

Female

If Low

Low estrone may indicate menopause or ovarian dysfunction.

If High

Elevated estrone may indicate excess body weight or hormone therapy. Discuss with your healthcare provider.

Estrone (E1): lifestyle and this value

Maintaining a healthy body weight may help regulate estrone levels, as fat tissue is a primary production site. Regular exercise, a balanced diet, and limiting alcohol consumption could support healthy estrogen balance. Always consult your healthcare provider before making significant changes.

Estrone (E1): frequently asked questions

What is estrone?

Estrone is a weaker estrogen that becomes dominant after menopause, mainly produced in fat tissue.

Why test estrone specifically?

Estrone testing may help evaluate postmenopausal hormonal status and overall estrogen activity.

Does body weight affect estrone?

Yes, fat tissue produces estrone, so body composition may influence your levels significantly.

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